The study some changes biochemical parameters in patient’s renal failure in before and after haemodialysis program

  • Salam Nahi Habbob Qalat Sukkar Sector Primary Health Care, The Department of Health Thiqar Governorate, Ministry of Health and Environment, Thiqar, Iraq.
  • Sajedha A.H. Khalil 1Medical Laboratory Tech.Dept, College of Health and Medical Technology, Middle technical university, Baghdad, Iraq.
Keywords: Haemodialysis, urea, creatinine, sodium, potassium

Abstract

          This study was designed to investigate changes in some biochemical parameters (urea, creatinine, sodium, potassium) at the end stage of renal disease (ESRD) patient on convenintial haemodialysis program.          The study was included collected of one hundred and thirteen (113) samples. Eighty-three (83) patients with end stage renal disease on haemodialysis program including (47) males and (36) females with a mean age of (43.3±18.0) years and range from (20-65) years. All the patients had been on dialysis twice per week for two hours each time. In addition, thirty from apparently healthy volunteers as control.          The subjects were fasted for twelve hours and the samples were drowning 30 minutes before haemodialysis and 30 minutes after haemodialysis.         This study showed highly significant differences in urea and creatinine concentrations before and after haemodialysis and when compared with control (before haemodialysis with control and after haemodialysis with control). The significant changes exist when the patients grouped according to gender (male and female) and age [(20-35), (36-50) and (51-65) years].         The electrolytes were varied in their changes. There was non-significant difference in sodium concentration except significant change in before and after haemodialysis when compared each with control; while potassium showed a highly significant changes except when pre dialysis compared to control and in the last two age groups (36-50) and (51-65) years in which there were no significant difference.

References

William McClellan, Bessie Young. (2009) “The Kidneys and How They Work". NIH Publication.

Unified Medical Language System, (NCI Thesaurus) at the National Library of Medicine ;( 2010).

Merriam-Webster's Medical Dictionary, by Merriam-Webster Inc. Published; (2010) Lister Hill National Center for Biomedical Communications

National Kidney Foundation (2002). "K/DOQI clinical practice guidelines for chronic kidney disease".

Abdoljalal Marjani: 2005 Effect of Haemodialysis On Plasma Lipid Peroxidation and Erythrocyte Antioxidant Enzymes in Gorgan (South East of Caspian Sea). The Internet Journal of Nephrology. Volume 2 Number 1.

Barry Kirschbaum: (2003) “The effect of hemodialysis on electrolytes and acid–base parameters. ʺ Clinica Chimica Acta 336:109– 113.

Ehab I. Mohamed and Eman S.D. Khalil. 2008 Bone Densitometric Analysis in Egyptian Hemodialysis Patients. Int J Biomed Sci; 4(2):120-124.

Maheshwari N, Ansari MR, Laghari MS and et al. 2010 Pattern of lip- id profile in patients on maintenance hemodialysis. Saudi J Kidney Dis Transpl; 21:565-70.

Erkan Dervifloĝlu, Ahmet Yilmaz, Erce Sevin and et al. 2007 ʺThe relationship between iron stores and corrected QT dispersion in patients undergoing hemodialysis". Anadolu Kardiyol Derg; 7: 270-4.

Isa Durmaz, Tahir Yagdi, Tanzer Calkavur and et al. 2003 ʺProphylactic Dialysis in Patients with Renal Dysfunction Undergoing On-Pump Coronary ArteryBypass Surgery". Ann Thorac Surg; 75:859-864.

Ali Monfared and Ahad Jafari Ghods. 2008 "Improvement of maximum corrected qt and corrected qt dispersion in electro- cardiography after kidney transplantation”. IJKD; 2:95-8.

Andrzej J. Jaroszyn´ ski, Andrzej Glowniak and et al. 2006 "Effect of haemodialysis on signal-averaged electrocardiogram P- wave parameters "Oxford Journals .Medicine.Nephrology Dialysis Transplantation.; 21: 425–430.

HL Tang, SH Wong, KH Chu and et al. 2006"Sodium ramping reduces hypotension and symptoms during haemodialysis”. Hong Kong Med J; 12:10-4.

Reza Hekmat, Abddollah Bahrami, Mostafa Ahmadi and et al. 2009 "The effect of the type of hemodialysis buffer on the QTC interval in patients on chronic hemodialysis”. Iran J Med Sci; 34(1): 29-35.

Luca Gabutti, Barbara Lucchini, Claudio Marone and et al. 2009 "Citrate- vs. acetate-based dialysate in bicarbonate haemoid- alysis: consequences on haemodynamics, coagulation, acid- base status and electrolytes".BMC Nephrology, 10:7.

Scott T. W. Morris, Eftychia Galiatsou, Grah A. Stewart and et al. 1999 "QT Dispers- ion Before and After Hemodialysis”. J Am Soc Nephrol: 160–163.

Jan Górski, Wim T. Hermens, Jacek Borawski and et al. 1997 Increased Fatty Acid-Binding Protein Concentr ation in Plasma of Patients with Chronic Renal Failure”. American Association for Cli- nical Chemistry, Inc.;43:193A-195.

Sadollah Shamsadini, S. Darvish-Moghaddam, H. Abdollahi and et al. 2006 Creatinine, blood urea nitrogen and thyroid hormone levels before and after haemodialysis. Health Journal; Volume 12 Nos 1&2.

Nauman Tarif, Yamani H, Bakhsh AJ and et al. 2008 Electrocardiography and Serum Potassium before and after Hemodialysis Sessions. Saudi J Kidney Dis Transpl; 19:47-53.

Published
2021-02-18
Section
Articles