Using polyphenolic extract for tubers Cyperus rotundus to prevent myocardial infarction
The present study aimed at determining the effect polyphenolic extract for tubers cyperus rotundus on myocardial infarction in female rats. In this study, 36 female rats were used and the animals were divided into 6 groups of each group containing (6 rats). Myocardial infarction was induced by injection of isoproterenol at (85 mg/kg) in the intraperitoneally of female rats at an interval of 24 h for two days. The results showed that the injection of isoproterenol in the intraperitoneally of female rats has caused a significant increase in levels of Troponin-I, lactate dehydrogenase(LDH), creatine phosphokinase (CPK), alanine transferase (ALT), aspartic transferase (AST) and necrosis in the second group compared to the first group. It was found in the current study that treatment of female rats with myocardial infarction with phenolic extract of tubers of cyperus rotundus has caused a significant decrease in levels of Troponin-I, lactate dehydrogenase (LDH), creatine phosphokinase (CPK), alanine transferase (ALT), aspartic transferase (AST). Necrosis decreased in the group treated with phenolic extract of tubers of cyperus rotundus. From this we conclude that the phenolic extract of cyperus rotundus of tubers has protective role against myocardial infarction
References: Abdel-Reheim, E. S. (2016) . “Cardioprotective Efficacy of Taurine on Lipid- Metabolism of Isoproterenol induced Myocardial Infraction .” International Journal of Pharmacy and Pharmaceutical Sciences., 8:135-141 Abi, B. G .; Mohamed, S. A .; Sivakumar, V. and Jaya, S. R. (2014) . “Cardioprotective Activity of Methanolic Extract of Croton Sparciflorus on Isoproterenol Induced Wister Albino Rats.” J Med Plants Stud., 2:1-8. –76. Auda, M. A.; Majid, A. and Al-Fartosi, K. G. (2018). Protective role of polyphenolic compounds extracted from cyperus rotundus rhizomes and taurine on troponin-I and some oxidant/antioxidants parameters of female rats treated with isoproterenol – induced myocardial infraction. Journal of Thi-Qar University., 13(2): 61-76. Bishop, M. L.; Fody, E. P. and Schoeff, L. (2005). “Clinical Chemistry:Principles, Procedures, Correlations.” 5th Edn. eds.Lippincott Williams and Wilkins.Philadelphia., 200–202,285,290, 370,372,503–508. Dang, G. K.; Parekar, R. R.; Kamat, S. K.; Scindia, A. M. and Rege, N. N. (2011). “AntiinFlammatory Activity of Phyllanthus Emblica, Plumbago Zeylanica and Cyperus Rotundus in Acute Models of Inflammation.” Phytother. Res., 25:904–908. Gayon, T. A. (1972). “Plant Phenolic.” Oliver and Boyed, Edinboura.,p: 254. Jagadeesh, G. S.; Meeran, M. F. N. and Selvaraj, P. (2016). “Activation of β1-Adrenoceptor Triggers Oxidative Stress Mediated Myocardial Membrane Destabilization in Isoproterenol Induced Myocardial Infarcted Rats: 7-Hydroxycoumarin and Its Counter Action.” European Journal of Pharmacology., 777: 70–77. Kesarwani, N. and Azmi, L . (2014). “Evaluation of Cardioprotective Effect of Tinospora Cordifolia against Isoprenaline Induced Myocardial Infraction in Rats.” International Journal of Current Microbiology and Applied Sciences., 5: 543–55. Kulkarni, J. M. and Swamy, A. V. (2015). “Cardioprotective Effect of Gallic Acid against DoxorubicinInduced Myocardial Toxicity in Albino Rats.” Indian J Health Sci., 8: 28–35. Majid, A.: Auda, M. A. and Al-Fartosi, K. G. (2018). Cardioprotective Activity of Polyphenolic Extract of Tubers of Cyperus Rotundus and Taurine against Isoproterenol - induced Myocardial Infraction in Rats: Troponin-I and Histological Findings. Journal of Global Pharma Technology. 10(03):479-487 Okigbo, R. N.; Anuagasi, C. L.; Amadi, J. E. and, Ukapabi, U. J. (2009). “Potential Inhibitory Effect of Some African Tuberous Plant Extracts on Escherichia Coli, Staphylococcus Aureus and Candida Albicans.” International Journal of Interactive Biology., 6: 91–98. Opie, L. H. (2004). “Heart Physiology from Cell to Circulation.” 4 Th Edn. Ed. Lippincott Williams& Wilkins. USA., 561. Parikh, H.; Tripathi, C. B.; Shah, P.; Pharm, V.; Ghori. M. and Goyal, R. K. (2015). “Investigation of the Cardioprotective Effects of Crataegus Oxycantha and Its Molecular Mechanism.” Curr Res Cardiol., 2:161-167. Raza, S. M.; Tomar, V. and Siddiqui, H. H. (2012). “Cardioprotective Effect of Alcoholic Extract of Cyperus Rotundus Rhizome on Isoproterenol - Induced Myocardial Necrosis in Rats.” International Journal of Pharmaceutical Sciences and Research (IJPSR)., 3: 2535–38. Sabeena, Farvin. K. H.; Anandan, R.; Kumar, S. H.; Shiny, K. S. Sankar, T. V. and Thankappan, T. K. (2004). “Effect of Squalene on Tissue Defense System in Isoproterenol-Induced Myocardial Infarction in Rats.” Pharmacol Res., 50: 231–36. Sadiya, Khwaja.; Tarique, Mahmood. and Hefazat, H. Siddiqui. (2016). “Effect of Ethanolic Extract of Cyperus Rotundus L. against Isoprenaline Induced Cardiotoxicity.”Indian Journal of Experimental Biology., 54: 670–75. Shi, M.; He, W.; Liu, Y.; Li, X.; Yang, S.; Xu, Q. (2013). “Protective Effect of Total Phenylethanoid
Glycosides from Monochasma Savatieri.” Phyto Medicine., 20: 1251–55. Shivakumar, S. I.; Suresh, H. M.; Hallikeri, C. S.; Hatapakki, B. C.; Handiganur, J. S.; Sankh, K. and Shivakumar, B. (2009). “Anticonvulsant Effect of Cyperus Rotundus Linn. Rhizomes in Upaganlawar, A.; Gandhi, C. and Balaraman, R. (2009). “Antioxidant Activities of Cyperus Rotundus L. Rhizome and Areca Catechu L. Seed.” Plant Foods Hum. Nutr., 64: 75–80.
Copyright (c) 2022 Journal of Education for Pure Science- University of Thi-Qar
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Journal of education for Pure Science (Jeds), University of Thi-Qar as publisher of the journal.
Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc. , will be allowed only with a written permission from Journal of education for Pure Science (Jeds), University of Thi-Qar.
Journal of education for Pure Science (Jeds), University of Thi-Qar, the Editors and the Advisory International Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal. In any way, the contents of the articles and advertisements published in the Journal of education for Pure Science (Jeds), University of Thi-Qar are sole and exclusive responsibility of their respective authors and advertisers.