Toxicopathological Study of Mercury Poisoning in male guinea pigs

Authors

  • University of Dhi Qar Faculty of Veterinary Medicine
  • Ministry of Education Department of Nasiriyah Education

DOI:

https://doi.org/10.32792/jeps.v12i1.142

Abstract

This study was carried out to evaluate the histopathological changes induced by mercuric chloride in
Twenty (20) male guinea pigs which were equally divided into two groups (n=10 for each). The mercuric
chloride was given orally at doses (4mg\kg) for second group (B), and distal water for group (A) as
control group. After 20 days of treatment, male guinea pigs were sacrificed, the histopathological
examination revealed that the mercuric chloride has wide space between seminiferous tubules and
showed an inadequately expansion and separation of spermatogenic and dilatation the space between
seminiferous tubules and scarcely any number of sperms and that might be because of HgCl2 actuated
oxidative pressure and expanded free-extremist in testis thusly might be causes decline number of sperms
in histological segment of testis. . A few investigations have detailed that the openness of creatures to
inorganic or natural types of mercury are joined by enlistment of oxidative stress and rise of creation of
receptive oxygen species (ROS) which lead to cell demise. The turn of events and development of male
conceptive tubules and seminiferous tubules in vertebrates rely upon the increment of testosterone
fixation. Testosterone is fundamental for endurance of the spermatogenic endothelium and speed up
seminiferous tubule improvement in the guinea pigs

References

Boujbiha M.A. Hamden K. Guermazi F. Bouslama A. (2009) Testicular toxicity in mercuric chloride

treated rats: Association with oxidative stress. Reprod Toxicol. 28: 81–89

Fitzgerald W. F. and Gill G. (1985). Depositional fluxes of mercury to the oceans. In: International

Conferenceo n HeavyM etalsi n the Environment, Vol. 1, CEP Consultants, Edinburgh, p p. 79-81.

Luna G.L. and LeeA.A. (1968). Manual of Histological staining methods of the armed forces. Institute of

pathology, (3rded.). McGraw-Hill Book Company, New York. USA. 169–188.

Mandava V. and Rao B.G. (2008) Antioxidative potential of melatonin against mercury induced

intoxication in spermatozoa in vitro. Toxicol In Vitro. 22: 935–942.

Mathur N. Pandey G. Jain G. (2010). Male Reproductive Toxicity of Some Selected Metals. A Review. J

Biol Sci. 10: 396–404.

Mathur, R.; Bharadwaj, S.; Shrivastava, S. and Mathur, A. (2002). Toxic effects of Vanadyl Sulphate: A

biochemical profile. Indian J Toxicol; 9(2): 77-82.

McVey M. Cooke G. Curran I. Chan H. Kubow S. (2008) An investigation of the effects of

methylmercury in rats fed different dietary fats and proteins: testicular steroidogenic enzymes and serum

testosterone levels. Food toxicol.Jan.46(1):270-9.

Nogueira C. Soares F.A. Nascimento P. Muller D. Rocha J. (2003). 2, 3- Dimercaptopropane -1-sulfonic

acid and meso-2,3-dimercaptosuccinic acid increase mercury- and cadmium-induced inhibition of samino

levulinate dehydratase. Toxicol. 184:85–95.

O‟Shea J.G. (1990). Two minutes with Venus, two years with mercury: mercury as antisyphilitic

chemotherapeutic agent. J. R. Soc. Med. 83: 392-3

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Published

2023-01-16

Issue

Vol. 12 No. 1 (2022): Journal of Education for Pure Science- University of Thi-Qar

Section

Articles

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