Toxicopathological Study of Mercury Poisoning in male guinea pigs
Abstract
This study was carried out to evaluate the histopathological changes induced by mercuric chloride in
Twenty (20) male guinea pigs which were equally divided into two groups (n=10 for each). The mercuric
chloride was given orally at doses (4mg\kg) for second group (B), and distal water for group (A) as
control group. After 20 days of treatment, male guinea pigs were sacrificed, the histopathological
examination revealed that the mercuric chloride has wide space between seminiferous tubules and
showed an inadequately expansion and separation of spermatogenic and dilatation the space between
seminiferous tubules and scarcely any number of sperms and that might be because of HgCl2 actuated
oxidative pressure and expanded free-extremist in testis thusly might be causes decline number of sperms
in histological segment of testis. . A few investigations have detailed that the openness of creatures to
inorganic or natural types of mercury are joined by enlistment of oxidative stress and rise of creation of
receptive oxygen species (ROS) which lead to cell demise. The turn of events and development of male
conceptive tubules and seminiferous tubules in vertebrates rely upon the increment of testosterone
fixation. Testosterone is fundamental for endurance of the spermatogenic endothelium and speed up
seminiferous tubule improvement in the guinea pigs
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