Effect of Monosodium Glutamate (MSG) On Tissue and Function of Liver and Kidney and Body Weight in Male Albino Mice

Authors

  • University of Thi-Qar, College of Education for Pure Sciences, Iraq
  • University of Thi-Qar, College of Education for Pure Sciences, Iraq

Keywords:

HDE, EEG, SQI, Monitor the Depth of Anaesthesia

Abstract

Delivering a proper amount of anesthetic agent is a critical factor directly related to the
health status of patients under surgery. Commercially available tools for measuring the level of
anesthesia including Bispectral Index (BIS) were developed to monitor the depth of anesthesia
(DoA), however, its combination of black box algorithm with hardware has limitations in
algorithmic interoperability. In addition, many hospitals cannot afford it due to its high cost. This
research aims to develop an intelligent model that can determine the DoA based on a signal from a
single channel electroencephalograph (EEG). In order to split EEG signals, a sliding window is
utilized in a segmentation technique. On each EEG segment, a hierarchical dispersion entropy,
abbreviated as HDE, was calculated. The EEG signal is then retrieved with HDE characteristics
after it has been split into four levels. Several other statistical metrics, such as Q-Q plots,
regression coefficients, and correlation coefficients, are used in order to evaluate the suggested
model that is based on HDE in terms of the BIS index. In addition, the suggested model is tested
against the BIS index to determine how well it can predict the quality of the power signals. The
findings indicate that the suggested model demonstrates an earlier reaction compared with the BIS
index whenever the state of the patient transitions from deep to moderate anesthesia. The accuracy
of the model that was proposed in this research came in at 95 percent

References

Zhu, F. G., Luo, X. G., Hou, C. J., Huo, D. Q., & Dang, P. (2019). Monitoring the depth of

anesthesia using Autoregressive model and Sample entropy. bioRxiv, 634675.

Monk TG, Saini V, Weldon BC, Sigl JC (2005) Anesthetic Management and OneYear Mortality

After Noncardiac Surgery. Anesthesia & Analgesia 100: 4-10.

Al-Kadi MI, Reaz MB, Ali MAM (2013) Evolution of Electroencephalogram Signal Analysis

Techniques during Anesthesia. Sensors 13: 6605-6635.

.Nguyen-Ky T, Wen P, Li Y (2009) Theoretical basis for identification of different anesthetic

states based on routinely recorded EEG during operation. Computers in Biology and Medicine 39:

-45.

Sebel PS, T Andrew B, Ghoneim MM, Rampil IJ, Padilla RE, et al. (2004) The incidence of

awareness during anesthesia: a multicenter United States study. Anesthesia & Analgesia 99: 833-

Johansen JW, Sebel PS (2000) Development and clinical application of electroencephalographic

bispectrum monitoring. Anesthesiology 93: 1336-1344.

Messner M, Beese U, Romstock J, Dinkel M, Tschaikowsky K (2003) The bispectral index

declines during neuromuscular block in fully awake persons. Anesthesia and Analgesia 97: 488-

Zanner R, Pilge S, Schneider G, Kreuzer M, Kochs EF (2006) Time delay of EEG index

calculation: analysis of Narcotrend, Bispectral and Cerebral State Index using recorded EEG

signals: A-107. European Journal of Anaesthesiology 23: 27.

Chen, S.J., Peng, C.J., Chen, Y.C., Hwang, Y.R., Lai, Y.S., Fan, S.Z. and Jen, K.K., 2016.

Comparison of FFT and marginal spectra of EEG using empirical mode decomposition to monitor

anesthesia. Computer methods and programs in biomedicine, 137, pp.77-85.

Benzy, V. K., & Jasmin, E. A. (2015). A combined wavelet and neural network based model for

classifying depth of anaesthesia. Procedia Computer Science, 46, 1610-1617.

Chowdhury, M. R., Madanu, R., Abbod, M. F., Fan, S. Z., & Shieh, J. S. (2021). Deep learning

via ECG and PPG signals for prediction of depth of anesthesia. Biomedical Signal Processing and

Control, 68, 102663.

Najafabadi, M.M., Villanustre, F., Khoshgoftaar, T.M., Seliya, N., Wald, R. and Muharemagic,

E., 2015. Deep learning applications and challenges in big data analytics. Journal of big data, 2(1),

pp.1-21.

Johansen, Jay W. "Update on bispectral index monitoring." Best practice & research Clinical

anaesthesiology 20, no. 1 (2006): 81-99.

Kim, D., Ahn, J.H., Heo, G. and Jeong, J.S., 2021. Comparison of Bispectral Index and Patient

State Index values according to recovery from moderate neuromuscular block under steady-state

total intravenous anesthesia. Scientific Reports, 11(1), pp.1-7.

Chen, Y.F., Fan, S.Z., Abbod, M.F., Shieh, J.S. and Zhang, M., 2021. Electroencephalogram

variability analysis for monitoring depth of anesthesia. Journal of Neural Engineering, 18(6),

p.066015.

Chowdhury, M. R., Madanu, R., Abbod, M. F., Fan, S. Z., & Shieh, J. S. (2021). Deep learning

via ECG and PPG signals for prediction of depth of anesthesia. Biomedical Signal Processing and

Control, 68, 102663

Li, T., & Wen, P. (2017). Depth of anaesthesia assessment using interval second-order difference

plot and permutation entropy techniques. IET Signal Processing, 11(2), 221-227.

Alsafy, Iman, and Mohammed Diykh. "Developing a robust model to predict depth of anesthesia

from single channel EEG signal." Physical and Engineering Sciences in Medicine (2022): 1-16.

Diykh, M., Li, Y., Wen, P. and Li, T., 2018. Complex networks approach for depth of anesthesia

assessment. Measurement, 119, pp.178-189.

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