Study of Antifungi activity and bioactive Compounds of brown alga extract
DOI:
https://doi.org/10.32792/jeps.v13i1.240Keywords:
Bioactive compounds, Laminaria, antifungi, Gc-mass.Abstract
The objective of this study was to determine bioactive compounds and antifungi of extracts of
Laminaria sp. against pathological fungi, which are Aspergillusniger, Candida albicans , and Candida
krusei, as the effective compounds extracted from this algae solvents were used (hot water and ethanol
alcohol) and the products of secondary metabolism from the aqueous extract were qualitatively detected,
which indicates existence of chemical compounds such as flavonoids and phenols Glycosides, terpenes
and carotenoids, Identified chemical compounds in the ethanolic extract of seaweed using gas
chromatography-mass spectrometry (Gc-mass). These compounds were Oleic acid, n-Hexadecanoic acid
, Fucosterol , Cyclohexane, 1,5-diethenyl-3-methyl-2-methylene-, (1.alpha.,3.alpha.,5.alpha.)- ,
Tetradecanoic acid and D-Mannitol. The aqueous extract of Laminaria sp. did not appear any biological
activity versus all the studied fungal species. While the ethanolic extract was found to be more effective
in its effect on pathogenic fungal species. The average zones of inhibition of the extract were (21.53,
21.46, 20.00) against C.albicans , A.niger and C.krusei , respectively.
References
Chowdhury, M. M. H.; Kubra, K.; Hossain, M. B.; Mustafa, M. G.; Jainab, T.; Karim, M. R.,
and Mehedy, M. E. (2015). Screening of Antibacterial and Anti-fungal Activity of Freshwater and
Marine Algae as a Prominent Natural Antibiotic Available in Bangladesh. International Journal of
Pharmacology., 11(7): 828-833.
Amr,A.(2009). Protective effect of green algae against Dimethylbenzanthracene (DMBA)-induced
Breast Cancer in Rats. International J. Cancer Research , 5(1):12-24.
Ireland ,C.; Copp , B.; Foster, M.; Mc Donald L.; Radishy , D. and Swersey C. (1993) .
Biomedical potential of marine natural products. In Attaway, D. and Zaborsky, O.(Eds.). Marine
biotechnology , pharmaceutical and bioactive natural products , Plenum Press , NY.143pp.
Mayer, A.; Rodríguez, A. D.; Taglialatela-Scafati, O. and Fusetani, N. (2013). Marine
pharmacology in 2009–2011: Marine compounds with antibacterial, antidiabetic, antifungal, antiinflammatory,
antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous
systems, and other miscellaneous mechanisms of action. Marine drugs., 11(7): 2510-2573.
Vlachos ,V.; Critchley , A. and Vanholy, A.(1997) . Antimicrobial activity of extracts from selected
Southern African marine algae. South African J. Science,Vol.93.328-33.
Siddhanata, S. K.; Ramavat, K. M. and Chauhan, V. D. (1991). Biomedical potential of marine
algae. J Sea Res Utilization, 15, 149-157.
Blunt, J. W.; Copp, B. R.; Hu, W. P.; Munro, M. H.; North cote, P. T. and Prinsep, M. R. (2007).
Marine natural products. Natural product reports., 24(1): 31-86.
Hammer, K. A. ; Carson, C. F. and Riley, T. V. (2002) . In vitro activity of Melaleucaalternifolia
(tea tree) oil against dermatophytes and other filamentous fungi. Journal of Antimicrobial
Chemotherapy., 50(2): 195- 199.
????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????Antioxidant Activities of Eucheuma sp.(Rhodophyceae) and Laminaria
sp.(Phaeophyceae). Turkish Journal of Agriculture-Food Science and Technology, 7(sp1), 154-159.
Muthamil, S.; Prasath, K. G.; Priya, A.; Precilla, P., and Pandian, S. K. (2020). Global
proteomic analysis deciphers the mechanism of action of plant derived oleic acid against Candida
albicans virulence and biofilm formation. Scientific reports, 10(1), 1-17.
Premjanu, N.; Jaynthy, C.; and Diviya, S. (2016). Antifungal activity of endophytic fungi isolated
from lanneacoromandelica–an insilico approach. Int. J. Pharm. Pharm. Sci, 8(5), 207-210.
Abdul, Q. A.;Choi, R. J.; Jung, H. A., and Choi, J. S. (2016). Health benefit of fucosterol from
marine algae: a review. Journal of the Science of Food and Agriculture, 96(6), 1856-1866.
Kantachumpoo, A., and Chirapart, A. (2010). Components and antimicrobial activity of
polysaccharides extracted from Thai brown seaweeds. Agriculture and Natural Resources, 44(2), 220-
Stirk, W.A.; Reinecke, D.L. and Van Staden, J. (2007). Seasonal Variation in Antifungal,
Antibacterial and Acetyl cholinesterase Activity in Seven South African seaweeds. Journal of
Applied Phycology., 19:271-276.
Boujaber, N.; Oumaskour, K.; Assobhei, O., and Etahiri, S. (2017). Antimicrobial activity of
different fractions obtained from Gelidiumsesquipedale and Laminariaochroleuca. Journal of Bio
Innovation, 6(3), 362-368.
Maioto, R., Ribeiro, I.; Girão, M., Carvalho, M. F., and Sampaio, A. (2022). Evaluation of
Antifungal Activities of Actinobacterial Extracts Isolated from Deep-Sea Laminariaochroleuca
against Pathogenic Fungi. In Medical Sciences Forum. MDPI.12(1) p:10
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