Investigate The Relation Between Polymorphism of ( CTLA-4 ) Gene And Asthma in Some Patients at Thi-Qar Province / IRAQ


  • Ahlam M. Kudair 1,2 Biology Department, Collage for Pure Science, University of Thi-Qar, Iraq.
  • Hassan R. Mubark 1,2 Biology Department, Collage for Pure Science, University of Thi-Qar, Iraq
  • Ali M. Chkheam 3Nursing Collage, University of Thi-Qar, Iraq


CTLA-4, polymorphism, Asthma


The present study was carried out at the Biology Department laboratories, for the period of (December
2017 to November 2018). The aim of the current study was to investigate polymorphism of CTLA-4 gene
in patients with Asthma. The study subject consisted of patients with asthma (74 females) and (26 males)
were their aged between (15-55) years, with (50 persons as control group. After DNA extraction, PCR
was made by using specific primers for the CTLA-4 gene, the study results explained the incidence of
polymorphisms in a samples of 25 out of asthma patients when using the restriction enzyme (BSTEII).
After analyzing the results by statistical analysis results showed that no association between the incidence
of Asthma and appearance of mutation in CTLA-4 gene when compared to the control group


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