Association of Irisin Hormone With Some Physiological And Inflammatory Parameters in Patients With Type 2 Diabetic Mellitus (T2DM) in Thi-Qar Province/ Iraq
AbstractThe present study aimed to assessment of irisin level in patients with the newly onset type 2 "diabetes mellitus" (T2D.M.) and the scanning the association of irisin value with some physiological and inflammatory parameters. This study comprised 60 individuals diagnosed in newly onset T2D.M. and 40 healthy contributors (control group). IL-6 and C-reactive protein(CRP) concentration was calculated in patient who involved in this study. Serum irisin levels in addition to inflammatory factors were evaluated by ELISA kit.
The present study showed a significant increasing (P ≤ 0.05) of glycohemoglobin (HbA1C) and FBS level in patient with DM2 compared with the control groups (6.88 ± 1.02 vs 4.15±0.56; 7.85 ± 1.89 vs 4.94 ± 0.40) respectively. Also, the results explained a significant increased (P ≤ 0.05) of T-Ch, Tg and LDL level in DM2 group compared with the control group (4.27±0.90 vs 4.23± 0.40; 2.14 ± 0.86 vs 1.89 ± 0.26; 2.84 ± 0.94 vs 2.23 ± 0.52) respectively. Whereas, the results showed a significant decrease (P ≤ 0.05) of irisin, insulin, C-peptide and HLD in DM2 group compared with the control group (22.32 ± 4.55 vs 27.81 ± 2.93; 18.29 ± 3.66 vs 27.27 ± 6.90; 3.12 ± 0.99 vs 6.03 ± 0.48; 1.0 ± 0.17 vs 1.61±0.37) respectively. On the other hand, the results of inflammatory parameters showed a significant increase (P ≤ 0.05) of IL-6 and CRP level compared with the control group (19.85 ± 4.97 vs 12.0 ± 1.23; 8.41 ± 2.11 vs 4.60 ± 0.35) respectively.
In correlation analysis the results showed a negative association between irisin and (HbA1c) (r= -0.152), glucose (r= -0.331), insulin (r= -0.156), HDL (r= -0.114) and BMI (r= -0.219). Whereas, the results showed positive correlation between irisin and IL-6 (r=0. 0.115), CRP (r= 0.153), C-peptide (r=0.013), T-Ch (r= 0.057), Tg (r=0.209) and LDL(r=0.035).
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