Effect of Rosuvastatin on the liver in male albino rats


  • 1Department of Biotechnology, Faculty of Biotechnology, Al-Qasim Green University, Babylon, Iraq
  • 2Department of Biology, College of Education for Pure Sciences, University of Thi-Qar, Thi-Qar, 64001, Iraq
  • 2Department of Biology, College of Education for Pure Sciences, University of Thi-Qar, Thi-Qar, 64001, Iraq


HMG-CoA enzyme, Hepatotoxicity, Rosuvastatin, Statins


Statins are among the most commonly used drugs to lower cholesterol, and rosuvastatin is one of
the most important statins, as it inhibits the HMG-CoA enzyme and targets the liver more than other
statins. Elderly patients usually receive these drugs to prevent cardiovascular disease. It is known that
exposure to drugs for a long time can lead to disorders in some organs, so the study current aimed to
find out the effect of rosuvastatin treatment on liver tissues and to what extent it affects biochemical
indicators of liver function in albino rats, serum levels of aspartate aminotransferase (AST), alanine
aminotransferase (ALT) and gamma-glutamyltransferase (GGT) were determined.
The results of the current study indicated that administration of rosuvastatin for 60 days led to a
change in serum levels (ALT, GGT and AST), these changes in biochemical tests cause
histopathological effects and the possibility of hepatotoxicity


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