Effect of Rosuvastatin on the liver in male albino rats

Authors

  • 1Department of Biotechnology, Faculty of Biotechnology, Al-Qasim Green University, Babylon, Iraq
  • 2Department of Biology, College of Education for Pure Sciences, University of Thi-Qar, Thi-Qar, 64001, Iraq
  • 2Department of Biology, College of Education for Pure Sciences, University of Thi-Qar, Thi-Qar, 64001, Iraq

DOI:

https://doi.org/10.32792/jeps.v13i3.360

Keywords:

HMG-CoA enzyme, Hepatotoxicity, Rosuvastatin, Statins

Abstract

Statins are among the most commonly used drugs to lower cholesterol, and rosuvastatin is one of
the most important statins, as it inhibits the HMG-CoA enzyme and targets the liver more than other
statins. Elderly patients usually receive these drugs to prevent cardiovascular disease. It is known that
exposure to drugs for a long time can lead to disorders in some organs, so the study current aimed to
find out the effect of rosuvastatin treatment on liver tissues and to what extent it affects biochemical
indicators of liver function in albino rats, serum levels of aspartate aminotransferase (AST), alanine
aminotransferase (ALT) and gamma-glutamyltransferase (GGT) were determined.
The results of the current study indicated that administration of rosuvastatin for 60 days led to a
change in serum levels (ALT, GGT and AST), these changes in biochemical tests cause
histopathological effects and the possibility of hepatotoxicity

References

Abdulwahhab, I. A. (2022). Effect of Hydroxychloroquine on lung , kidney and liver in adult

rabbits Oryctolagus cuniculus. Ph.D. thesis, College of Education for Pure Sciences, University of

Diyala, 1-207.

Al-Doaiss, A. A., Alarifi, S. A., and Jarrar, B. M. (2013). Hepatic histological and histochemical

alterations induced by rosuvastatin therapeutic doses. Pakistan Journal of Zoology, 45(1).

Ashraf, J., Khan, M. A., Minhaj, S., Khatti, S., Aarij, K. M., Shehzad, M., Khan, T. M. and

Khan, M. A. (2020). Statins and Abnormal Liver Function Tests: Is There a Correlation?. Cureus,

(8), 1-9.

Aziz, N. D., Mosa, A. U., and Hassan, A. H. (2020). A Comparative Study between Rosuvastatin

and Pitavastatin Toxicity on Liver and Kidney in Albino Rats. Indian Journal of Forensic Medicine &

Toxicology, 14(3), 2566-2572.

Bancroft, D, Stevens, A. and Turmer, R. (1996). Theory and practice of histological

technique, 4th Churchill Living Stone, Edinburgh, London Melbourne. 47- 6.

Bergmeyer, H. U., Herder, M., and Ref, R. (1986). International federation of clinical chemistry

(IFCC). Journal of clinical chemistry and clinical biochemistry, 24(7), 497-510.

Bryman, A. and Cramer, D. (2012). Quantitave date analysis with IBM SPSS 23 : A guide for

social scientist routledge.

Byrne, C. D. (2012). Dorothy Hodgkin Lecture 2012* Non

Downloads

Published

2023-11-04

Issue

Vol. 13 No. 3 (2023): JOURNAL OF COLLEGE OF EDUCATION FOR PURE SCIENCES

Section

Articles

License

Copyright (c) 2023 Journal of Education for Pure Science- University of Thi-Qar

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright Policy

Authors retain copyright of their articles published in the Journal of Education for Pure Science (JEPS).

By submitting their work, authors grant the journal a non-exclusive license to publish, distribute, and archive the article in all formats and media.

License

All articles published in JEPS are licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).

This license permits unrestricted use, distribution, and reproduction in any medium, provided that the original author(s) and the source are properly credited.

Author Rights

Authors have the right to:

  • Share their articles on personal websites, institutional repositories, and academic platforms

  • Reuse their work in future research and publications

  • Distribute the published version without restriction

Journal Rights

The journal retains the right to:

  • Publish and archive the articles

  • Include them in indexing and archiving systems such as LOCKSS and CLOCKSS

  • Promote and disseminate the published work

Responsibility

The contents of all articles are the sole responsibility of the authors. The journal, editors, and editorial board are not responsible for any errors, opinions, or statements expressed in the published articles.

Open Access Statement

JEPS provides immediate open access to its content, supporting the principle that making research freely available to the public enhances global knowledge exchange.

This work is licensed under a Creative Commons Attribution 4.0 International License.
https://creativecommons.org/licenses/by/4.0/