Prognostic value of FOXA1 expression in urinary bladder cancer
Abstract
The aim of currentstudy was to determine the expression of the FOXA1 protein in human bladder cancer, and demonstration of correlations between this parameters and clinical pathologic variables as grade and stage of tumour,non muscle invasive tumour and also by using this marker can classify bladder cancer in to basal and luminal type. The Current study is designed to detect the role of FOXA1expression in bladder carcinoma as a possible marker for detecting the biological behaviour of malignancy and its correlation with grade and muscle invasiveness for both diagnostic and prognostic purposes. The Current study focuses on a technique of immunohistochemistry for detection FOXA1expression in bladder cancer. The samples are collected randomly in southern Iraq in AL- Nasiriya city from AL Hussein teaching hospital. Number of samples is (100) of bladder tissue, ( 70)of bladder cancer tissue and (30) controls benign tissue. Results of this study reveal that FOXA1 expression is positive in( 29) out of (70) sample. The study approves that FOXA1 expressed was increased in low grade bladder cancer( 63.6%), FOXA1 expression high in the early tumour stage as (Ta) stage (94.7%), FOXA1 expression was high in non-muscle invasive (85.7%) ,FOXA1 has also shown an increase in male with bladder cancer represent (51.1).
So FOXA1can be used as a marker for assessment of bladder cancer aggressiveness. This study represents an important first step in Thi-qar because there are absence of a studies about this topic which to highlights this tumour and divides in to two types luminal and basal
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