Evaluation of amyloid protein expression in a neurodegenerative rat model impairs memory abilities by Ocimum basilicum extract
Keywords:
Amyloid protein, immunohistochemistry, Ocimum basilicum, memory abilitiesAbstract
Abstract
The main objective of this study was to evaluate of the neuroprotective potential effect of Ocimum
basilicum on amyloid protein expression in rat induced Alzheimer's disease. Fifty rats were divided into
five groups (ten rats each). Rats were treated orally with AlCl3 to induced AD. Group I (control group). Group II (AD group): supplemented orally with AlCl3 (17mg/kg/day) for four weeks. Group III (O .b
/AD group) supplemented concomitantly with oral rivastigmine (3 mg/kg /day). Group IV (O .b/AD group) supplemented concomitantly with oral OB (250mg/kg/day) and Group V (O. b/AD group)
supplemented concomitantly with oral O. b (500 mg/kg/day). The results showed that deposition of
amyloid protein expression was increased in positive group (AD induced rats) . Histological changes were observed in brain tissues of AD rats. Minor deposition of amyloid protein (arrow) in cerebral parenchyma was observed. However, the high dosing of the plant leaves extract (500 mg/kg) was more powerful than the low treatment with low dose (250 mg/kg) by decreasing accumulation of amyloid
protein expression. The results suggest that Ocimum basilicum can relieve symptoms and prevent the
progression of AD severity by improving memory function. It can be concluded that OB leaves were alleviated the memory impairment and learning abilities due to antioxidants activity of flavonoids, tannins and terpenoids
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