Haemodialysis effects on lipids Profile in patients with advanced renal disease

Abstract

This study attempts to investigate lipid profile (cholesterol, triglyceride, high density lipoprotein –cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C) and very low-density lipoprotein-cholesterol (VLDL-C)) would be induced potential due to haemodialysis program. The study included hundred and thirteen (113) samples. Eighty-three (83) patients with end stage renal disease on haemodialysis program including (47) males and (36) females with a mean age of (43.3±18.0) years and range from (20-65) years. All the patients had been on dialysis twice per week for two hours each time. In addition, thirty from healthy volunteers as control. All subjects were under obligation fasting for twelve hours and the samples were drowning before and 30 minutes after haemodialysis. Evaluation of serum concentrations of cholesterol, triglyceride, HDL-C, by enzymatic method while LDL-C and VLDL-C were calculated by the Friedewald formula. This study revealed that the changes of lipid profile (cholesterol, triglyceride, HDL-C, LDL-C and VLDL-C) were varied from small changes that statistically not significant between patients up to the highly significant changes between cholesterol and LDL-C before haemodialysis when compared to control. Significant changes are noticed between triglyceride and VLDL-C with control whereas high-density lipoprotein cholesterol didn't change. In male patient’s cholesterol and low LDL-C showed highly significant difference however the rest showed no significant difference. As well as pre and post haemodialysis when compared to control whereas in female lipid profile didn’t show any change.  According to age group (20-35) there was a highly significant difference between pre and post haemodialysis compared to control in cholesterol, triglyceride and LDL-C but not in HDL-C. The other two age groups the lipid profile did not show any changes.