Insulin resistance and the PC-1 gene sequence (ENPP1) (rs1044498) in people with Diabetes mellitus type- 2
Abstract
The research study was carried out between December and May 2023 at the Biotechnology
Research Unit of Thi-Qar at Mazaya University College. the current study aimed to identify the
genetic polymorphisms of 120 samples to investigate the possible association of PC-1 gene
polymorphism with the diabetes mellitus. The observed PCR amplicons were subjected to the DNA
sequencing procedure. The discovered variants were then localized based on where they were located
within the reference genomic DNA sequences. The recent findings showed that the samples under
investigation had genetic variations that were unevenly distributed. Besides, the rs1044498,
A248C,also the high frequency variant is usually detected in three polymorphic modes, AA, AC, CC.
Homozygous AA pattern discovered in the majority of patients (62.5%) and normal specimens
(60%). However, each observed SNP was taken a particular pattern of variation differ from its mate
in terms of the investigated samples. Ultimately, a statistical analysis is required to evaluate the
possible association of the SNPs is tested samples, with the diabetes mellitus. As a result, the PC1
polymorphism was found to be associated with type 2 diabetes mellitus and insulin resistance in the
current investigation.
References
* Abate, N., Chandalia, M., Satija, P., Adams-Huet, B., Grundy, S. M., Sandeep, S., ... & Mohan, V.
(2005). ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2
diabetes. Diabetes, 54(4), 1207-1213.
* Albegali, A. A., Shahzad, M., Ullah, M. I., Mahmood, S., & Rashid, M. (2019). Association of
genetic polymorphism of PC
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