Adiponectin gene polymorphism (rs2241766) in patients with coronary artery disease
Abstract
Abstract
The present study aimed to determine the association between the adiponectin gene (ADIPOQ gene) and coronary artery disease (CAD). Sixty individuals (40 patients and 20 healthy) were comprising in this study. The current results demonstrated significant relationship between TG genotype (22.5% ofCAD patients and 30% of healthy individuals) when compared with TT genotype. GG genotype was less common (12.5% and 15% of patients and control), as comparing with other genotypes. Also, there is no significant differences between GG genotype and TT genotype. There is no significant differences in allel frequencies between CAD patient and control group, while, T allel showed high frequency rate (76.25% and 70% in patients and control group respectively). Five mutations were determined within the studied region of the ADIPOQ gene using mutation surveyor program: 1 (20%) Deletion (g. 15324del C), 2 (40%) Transversion (g.15430G>T), 1 (20%) Transversion (g.15345A>C), 1 (20%) Transversion (g.15454T>A). In conclusion,the current study showed that rs2241766 polymorphisms affect in patients with coronary artery disease.
References
Global Burden of Disease Study 2013 Collaborators.Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the global burden of disease study 2013. Lancet 2015; 386:743–800.
Zhong, C.; Zhen, D.; Qian, Q. and Genshan, M. (2010). A lack ofassociation between adiponectin polymorphismsand coronary artery disease in a Chinese population. Genet. Mol. Biol., 33:428– 33.
Zdravkovic, S.; Wienke, A.; Pedersen, N. L.; Marenberg, M. E.; Yashin, A. I. and De Faire, U. (2002). Heritability of death fromcoronary heart disease: a 36-year follow-up of 20,966 Swedish twins. J. Intern. Med., 252:247–54.
Mayer, B.; Erdmann, J. and Schunkert, H. (2007). Genetics and heritability of coronary artery disease and myocardial infarction. Clin. Res. Cardiol., 96:1–7.
Dai, X.; Wiernek, S.; Evans, J. P. and Runge, M. S. (2016). Genetics of coronary artery disease and myocardial infarction. World J. Cardiol., 8:1–23.
Wang, Z. V. and Scherer, P. E. (2016). Adiponectin, the past two decades. J. Mol. Cell. Biol., 8:93–100.
Schnabel, R.; Messow, C. M.; Lubos, E. Klein, C. E.; Rupprecht, H. J.; Bickel, C.; Sinning, C.; Tzikas, S.; Keller, T.; Genth-Zotz, S.; Lackner, K. J.; Münzel, T. F. and Blenkenberg, S. (2008).
Association of adiponectin with adverseoutcome in coronary artery disease patients: results from the Athero Gene study. Eur. Hear J., 29:649–57.
Persson, J.; Lindberg, K.; Gustafsson, T. P.; Eriksson, P.; Paulsson-Berne, G. and Lundman, P.(2010). Low plasma adiponectin concentration is associated with myocardial infarction in young individuals. J. Intern. Med., 268:194–205.
Zhang, Z.; Li, Y.; Yang, X.; Wang, L.; Xu, L. and Zhang, Q.(2018). Susceptibility of multiple polymorphisms in ADIPOQ, ADIPOR1 and ADIPOR2 genes to myocardial infarction in Han Chinese. Gene., 658:10–7.
- Weyer, C.; Funahashi, T.; Tanaka, S.; Hotta, K.; Matsuzawa, Y.; Pratley, R. E, et al. (2001). Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab., 86(5):1930-5.
Hara, K.; Yamauchi, T.; Imai, Y.; Manabe, I.; Nagai, R. and Kadowaki, T. (2007). Reduced adiponectin level is associated with severity of coronary artery disease. Int. Heart J., 48:149–153.
Diah, M.; Lelo, A.; Muhktar, Z. and Lindarto, D. (2020). Analysis of two single-nucleotide polymorphisms (rs2241766 and rs1501299) of the adiponectin gene in patients with coronary artery disease and coronary slow flow. Med Glas (Zenica), 17(2): 341-345.
Al-Daghri, N. M.; Al-Attas, O. S.; Alokail, M. S.; Alkharfy, K. M. and Hussain, T. (2011). Adiponectin gene variants and the risk of coronary artery disease in patients with type 2 diabetes. Mol Biol Rep., 38(6):3703-8.
Eissa, A. T. (2016). Investigate the relation between Adiponectin gene variants and cardiovascular comorbidities and diabetes. International Journal of Health Sciences, 10(2): 183 - 189.
Piestrzeniewicz, K.; Luczak, K.; Komorowski, J.; Maciejewski, M.; Piechowiak, M.; Jankiewicz- Wika, J. and Goch, J. H.(2007). Obesity and adiponectin in acute myocardial infarction. Cardiol J., 14:29–36.
Scherer, P. E. (2006). Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes. 2006; 55(6):1537-45.
Hara, K.; Boutin, P.; Mori, Y.; Tobe, K.; Dina, C.; Yasuda, K.; et al. (2002). Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes. 51(2):536-40.
Association of adiponectin with adverseoutcome in coronary artery disease patients: results from the Athero Gene study. Eur. Hear J., 29:649–57.
Persson, J.; Lindberg, K.; Gustafsson, T. P.; Eriksson, P.; Paulsson-Berne, G. and Lundman, P.(2010). Low plasma adiponectin concentration is associated with myocardial infarction in young individuals. J. Intern. Med., 268:194–205.
Zhang, Z.; Li, Y.; Yang, X.; Wang, L.; Xu, L. and Zhang, Q.(2018). Susceptibility of multiple polymorphisms in ADIPOQ, ADIPOR1 and ADIPOR2 genes to myocardial infarction in Han Chinese. Gene., 658:10–7.
- Weyer, C.; Funahashi, T.; Tanaka, S.; Hotta, K.; Matsuzawa, Y.; Pratley, R. E, et al. (2001). Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab., 86(5):1930-5.
Hara, K.; Yamauchi, T.; Imai, Y.; Manabe, I.; Nagai, R. and Kadowaki, T. (2007). Reduced adiponectin level is associated with severity of coronary artery disease. Int. Heart J., 48:149–153.
Diah, M.; Lelo, A.; Muhktar, Z. and Lindarto, D. (2020). Analysis of two single-nucleotide polymorphisms (rs2241766 and rs1501299) of the adiponectin gene in patients with coronary artery disease and coronary slow flow. Med Glas (Zenica), 17(2): 341-345.
Al-Daghri, N. M.; Al-Attas, O. S.; Alokail, M. S.; Alkharfy, K. M. and Hussain, T. (2011). Adiponectin gene variants and the risk of coronary artery disease in patients with type 2 diabetes. Mol Biol Rep., 38(6):3703-8.
Eissa, A. T. (2016). Investigate the relation between Adiponectin gene variants and cardiovascular comorbidities and diabetes. International Journal of Health Sciences, 10(2): 183 - 189.
Piestrzeniewicz, K.; Luczak, K.; Komorowski, J.; Maciejewski, M.; Piechowiak, M.; Jankiewicz- Wika, J. and Goch, J. H.(2007). Obesity and adiponectin in acute myocardial infarction. Cardiol J., 14:29–36.
Scherer, P. E. (2006). Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes. 2006; 55(6):1537-45.
Hara, K.; Boutin, P.; Mori, Y.; Tobe, K.; Dina, C.; Yasuda, K.; et al. (2002). Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes. 51(2):536-40.
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Journal of Education for Pure Science- University of Thi-Qar
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Journal of education for Pure Science (Jeds), University of Thi-Qar as publisher of the journal.
Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc. , will be allowed only with a written permission from Journal of education for Pure Science (Jeds), University of Thi-Qar.
Journal of education for Pure Science (Jeds), University of Thi-Qar, the Editors and the Advisory International Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal. In any way, the contents of the articles and advertisements published in the Journal of education for Pure Science (Jeds), University of Thi-Qar are sole and exclusive responsibility of their respective authors and advertisers.
