Adiponectin gene polymorphism (rs2241766) in patients with coronary artery disease
DOI:
https://doi.org/10.32792/jeps.v13i4.375الملخص
Abstract
The present study aimed to determine the association between the adiponectin gene (ADIPOQ gene) and coronary artery disease (CAD). Sixty individuals (40 patients and 20 healthy) were comprising in this study. The current results demonstrated significant relationship between TG genotype (22.5% ofCAD patients and 30% of healthy individuals) when compared with TT genotype. GG genotype was less common (12.5% and 15% of patients and control), as comparing with other genotypes. Also, there is no significant differences between GG genotype and TT genotype. There is no significant differences in allel frequencies between CAD patient and control group, while, T allel showed high frequency rate (76.25% and 70% in patients and control group respectively). Five mutations were determined within the studied region of the ADIPOQ gene using mutation surveyor program: 1 (20%) Deletion (g. 15324del C), 2 (40%) Transversion (g.15430G>T), 1 (20%) Transversion (g.15345A>C), 1 (20%) Transversion (g.15454T>A). In conclusion,the current study showed that rs2241766 polymorphisms affect in patients with coronary artery disease.
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Diah, M.; Lelo, A.; Muhktar, Z. and Lindarto, D. (2020). Analysis of two single-nucleotide polymorphisms (rs2241766 and rs1501299) of the adiponectin gene in patients with coronary artery disease and coronary slow flow. Med Glas (Zenica), 17(2): 341-345.
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Hara, K.; Boutin, P.; Mori, Y.; Tobe, K.; Dina, C.; Yasuda, K.; et al. (2002). Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes. 51(2):536-40.
Association of adiponectin with adverseoutcome in coronary artery disease patients: results from the Athero Gene study. Eur. Hear J., 29:649–57.
Persson, J.; Lindberg, K.; Gustafsson, T. P.; Eriksson, P.; Paulsson-Berne, G. and Lundman, P.(2010). Low plasma adiponectin concentration is associated with myocardial infarction in young individuals. J. Intern. Med., 268:194–205.
Zhang, Z.; Li, Y.; Yang, X.; Wang, L.; Xu, L. and Zhang, Q.(2018). Susceptibility of multiple polymorphisms in ADIPOQ, ADIPOR1 and ADIPOR2 genes to myocardial infarction in Han Chinese. Gene., 658:10–7.
- Weyer, C.; Funahashi, T.; Tanaka, S.; Hotta, K.; Matsuzawa, Y.; Pratley, R. E, et al. (2001). Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab., 86(5):1930-5.
Hara, K.; Yamauchi, T.; Imai, Y.; Manabe, I.; Nagai, R. and Kadowaki, T. (2007). Reduced adiponectin level is associated with severity of coronary artery disease. Int. Heart J., 48:149–153.
Diah, M.; Lelo, A.; Muhktar, Z. and Lindarto, D. (2020). Analysis of two single-nucleotide polymorphisms (rs2241766 and rs1501299) of the adiponectin gene in patients with coronary artery disease and coronary slow flow. Med Glas (Zenica), 17(2): 341-345.
Al-Daghri, N. M.; Al-Attas, O. S.; Alokail, M. S.; Alkharfy, K. M. and Hussain, T. (2011). Adiponectin gene variants and the risk of coronary artery disease in patients with type 2 diabetes. Mol Biol Rep., 38(6):3703-8.
Eissa, A. T. (2016). Investigate the relation between Adiponectin gene variants and cardiovascular comorbidities and diabetes. International Journal of Health Sciences, 10(2): 183 - 189.
Piestrzeniewicz, K.; Luczak, K.; Komorowski, J.; Maciejewski, M.; Piechowiak, M.; Jankiewicz- Wika, J. and Goch, J. H.(2007). Obesity and adiponectin in acute myocardial infarction. Cardiol J., 14:29–36.
Scherer, P. E. (2006). Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes. 2006; 55(6):1537-45.
Hara, K.; Boutin, P.; Mori, Y.; Tobe, K.; Dina, C.; Yasuda, K.; et al. (2002). Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes. 51(2):536-40.
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