Assessment of IL-17 and IL-4 serum levels and their relationship to psoriasis pateints

الملخص

Psoriasis is an immune-mediated disease (a disease with an unclear cause that is characterized by
inflammation caused by dysfunction of the immune system) that causes inflammation in the
body.This study included 100 patients and 50 healthy.Aquestionnaire was included sex and age of
psoriatic patients and healthy subjects, also, psoriatic patients were distributed according to the
period of infection, family history, severity of psoriasis, and comorbidities of psoriasis. Enzymelinked
immunosorbent assay (ELISA) used to measure the concentration levels of cytokines
interleukin-17 (IL-17) and interleukin-4(IL-4) in the serum of the studied samples from both groups.
The present results showed no significant differences between psoriatic patients and healthy subjects
according to age(P=0.247) andsex (P=0.643), while asignificant differences was observed
betweenpsoriatic patients inperiod of infection (P=0.000), family history (P=0.001), severity of
psoriasis (P=0.000) and comorbidities of psoriasis (P=0.000), as well, the current results indicated an
increase in the concentration level of IL-17 in psoriatic patients (150.61±55.7 pg/mL) compared with
its concentration levels in healthy individuals (96.55±34.pg/mL), with significant difference (P=0.00)
at (P≤0.05). Adecrease in the concentration levels of IL-4 in psoriatic patients (136.8±51.9 pg/mL)
was observed in this study compared with its concentration levels in healthy individuals
(193.84±69.10 pg/mL) with a significant difference between the two groups (P=0.002). It can be
concluded that there is an immunologic imbalance of T cells in psoriasis, which is associated with the
upregulation of IL-17 and the downregulation of IL-4 in the circulation. This immune dysregulation,
which plays a key role in the disease progression.