The Role of Interleukin-17 in Heart and Vascular Diseases at Thi-Qar Governorate
DOI:
https://doi.org/10.32792/jeps.v13i4.372الكلمات المفتاحية:
Heart and Vascular diseases, IL-17, smoking.الملخص
Abstract:
The objective of this study is to assess Interleukin-17 in cardiovascular patients. This study was conducted in the heart center in Thi-Qar Governorate, during the period between1/12/2023 to 1/4/2024. The study was investigated to measure Interleukin-17 (IL-17) levels in the serum using Enzyme-Linked Immunosorbent Assay (ELISA). The study included 100 participants: 50 patients with heart and vascular diseases and 50 healthy subjects serving as controls. The statistical analysis showed a significant increase in serum the mean concentration of (IL-17) in patients (10.90±4.28) pg/ml compared to the healthy control group (8.108±3.72) pg/ml with a statistically significant difference (P=0.001). So, it is concluded that the high level of IL-17 in the serum has to do with cardiovascular diseases.
المراجع
M. Fakhry and A. Al-Aseel S. Worthan, “Prevention of cardiovascular disease. King Fahd University Hospital in Al-Khobar”. University of Dammam. 2017.
M. Veldhoen, Interleukin 17 is a chief orchestrator of immunity. Nature Immunology. Vol.18, pp. 612–621. 2017.
X. Zhang and F. Pei M. Zhang C. Yan M. Huang T. Wang Y. Han, “Interleukin-17A gene variants and risk of coronary artery disease: A large angiography-based study”. Clinica Chimica Acta 412, pp. 327–331. 2011.
G. Allam and A. Abdel-Moneim A. Gaber, “The pleiotropic role of interleukin-17 in atherosclerosis”. Biomedicine &Pharmacotherapy journal. 106. Pp.1412–1418. 2018.
E. Attia and A. Salman, “The Role of CXCR3 in Cardiovascular Disease Patients in Thi-Qar Province, Iraq”. NeuroQuantology: pp.211-214. 2022.
A. Csiszar and Z. Ungvari, “Synergistic effects of vascular IL-17 and TNFa may promote coronary artery disease”. Medical Hypotheses. 63, pp. 696–698. 2004.
S. Zhou and J. Yuan M. Liao N. Xia T. Tang J. Li J. Jiao W. Dong S. Nie Z. Zhu W. Zhang B. Lv H. Xiao Q. Wang X. Tu Y. Liao G. Shi X. Cheng, “IL-17A promotes ventricular remodeling after myocardial infarction,” J Mol Med. 92: pp.1105–1116. 2014.
M. Mora-Ruíz and F. Blanco-Favela A. Rueda M. Legorreta-Haquet L. Chávez-Sánchez, “Role of interleukin-17 in acute myocardial infarction”. Molecular Immunology 107. Pp. 71–78. 2019.
H. Wada and M. Nakamura S. Inoue K. Kudo T. Hanawa Y. Iwakura F. Kobayashi H. Kamma S. Kamiya K. Ito P. Barnes H. Takizawa, “Dual interleukin‑17A/F deficiency protects against acute and chronic responses to cigarette smoke exposure in mice”. Scientific Reports 11:11508. 2021.
T. Simon and S. Taleb N. Danchin L. Laurans B. Rousseau S. Cattan J. Montely O. Dubourg A. Tedgui S. Kotti Z. Mallat, “Circulating levels of interleukin-17 and cardiovascular outcomes in patients with acute myocardial infarction”. European Heart Journal .34, pp.570–577. 2013.
التنزيلات
منشور
إصدار
القسم
الرخصة
الحقوق الفكرية (c) 2023 Journal of Education for Pure Science- University of Thi-Qar
هذا العمل مرخص بموجب Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The Authors understand that, the copyright of the articles shall be assigned to Journal of education for Pure Science (JEPS), University of Thi-Qar as publisher of the journal.
Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc. , will be allowed only with a written permission from Journal of education for Pure Science (JEPS), University of Thi-Qar.
Journal of education for Pure Science (JEPS), University of Thi-Qar, the Editors and the Advisory International Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal. In any way, the contents of the articles and advertisements published in the Journal of education for Pure Science (JEPS), University of Thi-Qar are sole and exclusive responsibility of their respective authors and advertisers.
