The effect of diabetes on the development of skin lesions in patients in infected with  cutaneous leishmaniasis in Thi-Qar province , Iraq.

Zainab  K. Aouda; Zainab   A. Mohammad; Hind  M. Mousa

doi:10.32792/jeps.v14i1.383

المؤلفون

Zainab K. Aouda
Zainab A. Mohammad
Hind M. Mousa

DOI:

https://doi.org/10.32792/jeps.v14i1.383

الكلمات المفتاحية:

leishmaniasis, cutaneous leishmaniasis, diabetes,Iraq.

الملخص

Abstract:
Cutaneous Leishmaniasis is the most common form of Leishmaniasis, it affects the skin and cause a painless and chronic papule at the site of the infected sand fly bite. The current study amied to assess the associated-risk determinants for cutaneous leishmaniasis in patients with diabetes compared to patients without diabetes. The direct stain method used to diagnose the cutaneous leishmaniasis. Blood samples were collected form 45 confirmed cutaneous leishmaniasis patients for the purpose of measuring HBA1C for patients with cutaneous leishmaniasis. The results of current study showed that 276 out of 315 (87.61%) were infected with cutaneous leishmaniasis by microscopic examination. Significant differences (P<0.05) were recorded in the prevalence of cutaneous leishmaniasis according to patient sex and the infected males 65.21% more than infected females 34.78%. Eleven out of 45 cutaneous leishmaniasis patients were suffered from diabetes with prevalence 24.44%. A high association between diabetes and increase in the size of the skin lesions was recorded in current study, the prevalence of diabetic patients with large skin lesions 17.78% higher than the prevalence of diabetic patients with small skine lesions 6.67%, also an association between diabetes and increased the number of cutaneous skin lesions was reported. The prevalence of cutaneous leishmaniasis patients with diabetes who suffered from multiple skin lesions was 13.33% higher than the prevalence of cutaneous leishmaniasis patients with diabetes who had a single skin lesions 11.11% and an association between diabetes and non-response to treatment of cutaneous leishmaniasis patients was recorded, the prevalence of cutaneous leishmaniasis patients with diabetes who did not respond to treatment was 15.56% higher than the prevalence of cutaneous leishmaniasis patients with diabetes who responded to treatment 8.89%. The results of current study demonstrated a significant relationship between diabetes and cutaneous leishmanasis in distinct risk determinants. Also, the study showed that the diabetes increased the severity of active cutaneous leihmaniasis.

المراجع

.Uzun, S., Gürel, M. S., Durdu, M., Akyol, M., Fettahlıoğlu Karaman, B., Aksoy, M., ... & Harman, M. (2018). Clinical practice guidelines for the diagnosis and treatment of cutaneous leishmaniasis in Turkey. International journal of dermatology, 57(8), 973-982.

Alsaad, R. K. A., & Kawan, M. H. (2021). An epidemiological study of cutaneous

parasitology,

dogs.

in

human

(3),

Annals

leishmaniosis

of

and

–433.

https://doi.org/10.17420/ap6703.355.

Gurel, M. S., Tekin, B., & Uzun, S. (2020). Cutaneous leishmaniasis: A great imitator. Clinics in dermatology, 38(2), 140-151.

Bilgic-Temel, A., Murrell, D. F. and Uzun, S. (2019). ‘Cutaneous leishmaniasis: A neglected disfiguring disease for women.

Sadlova, J., Myskova, J., Lestinova, T., Votypka, J., Yeo, M., & Volf, P. (2017).

Leishmania donovani development in Phlebotomus argentipes: comparison of promastigote-

and

amastigote-initiated

(4),

Parasitology,

infections.

–410.

https://doi.org/10.1017/S0031182016002067.

Cecílio, P., Cordeiro-da-Silva, A., & Oliveira, F. (2022). Sand flies: Basic information on the vectors of leishmaniasis and their interactions with Leishmania parasites. Communications biology, 5(1), 305. https://doi.org/10.1038/s42003-022-03240-z.

Reimão, J. Q., Coser, E. M., Lee, M. R., & Coelho, A. C. (2020). Laboratory Diagnosis of Cutaneous and Visceral Leishmaniasis: Current and Future Methods. Microorganisms, 8(11), 1632. https://doi.org/10.3390/microorganisms8111632.

Ali, M. A., Khamesipour, A., Rahi, A. A., Mohebali, M., Akhavan, A., Firooz, A. and Keshavarz, H. V. (2018). ‘Epidemiological study of leishmaniasis in some Iraqi provinces’, J. Men. Heal., 14(4): 18–24. doi: 10.22374/1875-6859.14.4.4.

Al-Alawi, H . M (2020) . Study of some epidemiological, biochemical and molecular aspects of the Leishmania parasite Dermatology in Najaf Al-Ashraf province , MCQ . Thesis . College of Education for Girls . University of Kufa . 124 PP.

Turki, W. Q., Reda, J. I. A. ., Abbas, R. H. ., & Rdaali, A. R. R. F. . (2022). Survey Study of Cutaneous Leishmaniasis in Baghdad . Ibn AL-Haitham Journal For Pure and Applied Sciences, 35(3), 1–4. https://doi.org/10.30526/35.3.2740.

Al-Waaly, A.B.M.; Shubber, H.W.K. (2020). Epidemiological study of cutaneous leishmaniasis in Al-Diwaniyah Province, Iraq. Eurasia. J .Bio.Sci., 14, 269-273 pp.

Al-Mosawi, N. AJ. AK. (2015). Investigate of Cutaneous Leishmaniasis and knowledge of the role heat shock protein HSP70 in the immune response in the province of Thi Qar . M.Sc. College of Education for pure science. University of Thi-Qar. 90 pp.

Flaih, M. H. (2020). Epidemiology and Molecular study of Leishmania tropica Isolated from Cutaneous Lesions in Thi-Qar Province, Iraq. Ph.D. Thesis. College of Education for pure science. University of Thi-Qar. 165 pp.

Musa, F. G. (2022). Detection of cutaneous Leishmania parasite in skin tissue using immunohistochemistry technique.MCQ. Thesis. College of Education for pure science. University of Thi-Qar. 215 PP.

Atshan, A. M. (2014). Epidemiological study for distribution of Cutaneous and Viseral Leishmanasis in Thi-Qar province and test efficiency some pesticides on the insect vector. M.Sc. Thesis. College of Science.University of Thi-Qar. 106.

Abul-Doanej, H. A. I. (2014). Study of Epidemiolical aspects for Leishmaniasis and diagnosis of the Parasite by using NestedKinetoplast Minicircle DNA-PCR technique In the Province of Maisan-Iraq. M.Sc .College of Education for Pure Science. University of Basrah. 93 pp.

Rahmanian, P., Bryson, A. L., Binnicker, M. J., Pritt, B. S., & Patel, R. (2018).

Syndromic panel-based testing in clinical microbiology. Clinical microbiology reviews, 31(1), e00024-17.

Al-Mafraji, K. H., Al-Rubaey, M. G. and Alkaisy, K. K. (2008). ‘ClincoEpidemiological Study of Cutaneous Leishmaniasis in Al-Yarmouk Teaching Hospital’, Iraqi J. Comm. Med., 3:194–197.

Al-Difaie, R. S. (2013). Prevalence of Cutaneous Leishmaniasis in ALQadissia province and the evaluation of treatment response by pentostam with RT-PCR. Wasit Uni. Coll. Sci.

Al-Mayali, H. M. (1998) . Evaluation and use of some immunological tests in an epidemiological study of leishmaniasis in Al-Qadisiyah province , Ph.D. Thesis. College of Education for pure science. University of Al-Qadisiyah. 196 pp.

Al-Hassani, M. K. K. T. (2016). Epidemiological, Molecular and Morphological Identification of cutaneous leishmaniasis and, It‟s insect vectors in Eastern Al-Hamzah district,AlQadisiya province. College. Education. University of AL-Qadisiya .101pp.

Al-Lami S.(2021). Epidemiological and diagnostic and genetics study for leishmania parasite in Misan government. M.Sc. College of Education for pure science. University of Thi-Qar. 76 pp .

Bachi, F., Icheboudene, K., Benzitouni, A., Taharboucht, Z., & Zemmouri, M. (2019).

Épidémiologie de la leishmaniose cutanée en Algérie à travers la caractérisation moléculaire. Bull Soc Pathol

Lago, A. S., Lima, F. R., Carvalho, A. M., Sampaio, C., Lago, N., Guimarães, L. H., ... & Carvalho, E. M. (2020, December). Diabetes modifies the clinic presentation of cutaneous leishmaniasis. In Open Forum Infectious Diseases (Vol. 7, No. 12, p. ofaa491). US: Oxford University Press.